To some degree, the basics of a functioning home office couldn't be simpler. If you've got a desk, a chair, a personal computer you're comfortable with, and an empty corner to put them all, well then, you've got yourself a home office. If you want to get the most out of your work space, however, you're going to have to put some thought into each of these elements.
For example, if you have at least some usable vision, you'll want to choose a space with ample lighting sources—and you'll want to position your furniture and equipment to minimize glare. Equipping your monitor with an anti-glare screen is another good idea.
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